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Connection between tramadol and hip fractures found
The use of the pain reliever Tramadol appears to be associated with an increased risk of hip fractures compared to other pain relievers.
A recent study by the Central South University in the People's Republic of China found that the pain reliever tramadol is associated with an increased risk of hip fractures compared to the use of other pain relievers. The results of the study were published in the English-language journal "Journal of Bone and Mineral Research".
At what level of pain is Tramadol used?
Pain relievers are actually supposed to reduce pain without causing negative health effects. However, if people take the pain reliever Tramadol, which is used for moderate to severe pain, this is associated with an increased risk of hip fractures compared to the use of other pain relievers.
What are the side effects of Tramadol?
Tramadol is actually known for side effects such as dizziness, tiredness, headache, nausea and vomiting. However, the new data show that users also suffer from hip fractures more frequently.
Researchers compared different pain relievers
The latest analysis by Central South University compared the use of tramadol with the use of codeine, naproxen, ibuprofen, celecoxib and etoricoxib in adults aged 50 years or older.
What was found?
During the one-year follow-up period of the examination, a total of 518 hip fractures occurred in 146,956 participants taking tramadol. This corresponded to an additional new hip fracture per 1,000 person-years compared to taking codeine (3.7 versus 2.9).
Comparison with other pain relievers
In addition, up to 1.5 additional new fractures occurred per 1,000 person-years when taking Tramadol compared to taking Naproxen, Ibuprofen, Celecoxib and Etoricoxib.
The risk of hip fractures must be considered
In view of the significant impact of hip fracture on morbidity, mortality and health costs, the results found indicate that the risk of fractures associated with tramadol must be taken into account in clinical practice and in the treatment guidelines. (as)
Author and source information
This text corresponds to the requirements of the medical literature, medical guidelines and current studies and has been checked by medical doctors.
- Jie Wei, Nancy E Lane, Marcy B Bolster, Maureen Dubreuil, Chao Zeng et al .: Association of Tramadol Use With Risk of Hip Fracture, in Journal of Bone and Mineral Research (published February 5, 2020), Journal of Bone and Mineral Research