Music for pain?
The therapeutic effects of music have been investigated in various previous studies. Researchers have now found that combining music with one of four pain relievers enables a promising complementary strategy for pain management.
A recent study by the University of Utah found that a combination of music and pain relievers is beneficial in treating pain. The results of the study were published in the English language journal "Frontiers in Neurology".
Inflammatory pain was reduced by 90 percent
In particular, a combination of ibuprofen and music improved analgesic results in a mouse model with inflammation pain by more than 90 percent, while other combinations reduced inflammation by 70 percent. The medicines work without the music, but can cause toxicity and side effects. The key is to combine the right medication with music, which means fewer medications are needed for analgesic effects, the study authors report.
Trial took place on mice
The researchers evaluated the new strategy using two pain models. One model mimics inflammatory pain (carrageenan model) and the other model mimics surgical pain (plantar incision). The mice in the study were divided into two groups. The control group was exposed to ambient noise, while the music intervention group listened to three three-hour sections of Mozart's music for 21 days. The study was performed four times to analyze mating with ibuprofen (25 mg / kg), cannabidiol (100 mg / kg), levetiracetam (400 mg / kg) and the galanin analog NAX 5055 (4 mg / kg). Both the control group and the music group received a suboptimal dose of each drug in order to evaluate the analgesic effect of the music in the pain models. In combination with music, ibuprofen reduced the pain response in the inflammation pain model by 93 percent compared to the drug alone. In addition, music and cannabidiol or NAX 5055 reduced swelling in the inflammation pain model by 21 and 9 percent, respectively. Music alone also reduced the pain in the surgical pain model by 77 percent.
More research is needed
There is increasing evidence that music interventions can relieve pain when used alone or in combination with other therapies. It is exciting to think about what this could mean for the anti-inflammatory effects of music interventions and where the current research will lead to next, say the authors of the study. The study also examined the combination of music with various epilepsy medications, but the experimental design was insufficient to take advantage of the complexity of drug dosage and administration to evaluate this therapeutic strategy. The study was limited to two pain models and did not examine pain caused by nerve injuries (neuropathic pain). In addition, the musical intervention in the study was limited to pieces by Mozart. Mice also hear different frequencies than humans and the effect of the volume or duration of the music remains unclear. Further research is needed to determine whether similar results could also apply to humans. (as)